Skip to comments.Common virus kills cancer, study finds
Posted on 06/21/2005 3:53:57 PM PDT by Tumbleweed_Connection
A common virus that is harmless to people can destroy cancerous cells in the body and might be developed into a new cancer therapy, U.S. researchers said on Tuesday.
The virus, called adeno-associated virus type 2, or AAV-2, infects an estimated 80 percent of the population.
"Our results suggest that adeno-associated virus type 2, which infects the majority of the population but has no known ill effects, kills multiple types of cancer cells yet has no effect on healthy cells," said Craig Meyers, a professor of microbiology and immunology at the Penn State College of Medicine in Pennsylvania.
"We believe that AAV-2 recognizes that the cancer cells are abnormal and destroys them. This suggests that AAV-2 has great potential to be developed as an anti-cancer agent," Meyers said in a statement.
He said at a meeting of the American Society for Virology that studies have shown women infected with AAV-2 who are also infected with a cancer-causing wart virus called HPV develop cervical cancer less frequently than uninfected women do.
AAV-2 is a small virus that cannot replicate itself without the help of another virus. But with the help of a second virus it kills cells.
For their study, Meyers and colleagues first infected a batch of human cells with HPV, some strains of which cause cervical cancer.
They then infected these cells and normal cells with AAV-2.
After six days, all the HPV-infected cells died.
The same thing happened with cervical, breast, prostate and squamous cell tumor cells.
All are cancers of the epithelial cells, which include skin cells and other cells that line the insides and outsides of organs.
"One of the most compelling findings is that AAV-2 appears to have no pathologic effects on healthy cells," Meyers said.
"So many cancer therapies are as poisonous to healthy cells as they are to cancer cells. A therapy that is able to distinguish between healthy and cancer cells could be less difficult to endure for those with cancer."
AAV-2 is being studied intensively as a gene therapy vector -- a virus modified to carry disease-correcting genes into the body. Gene therapy researchers favor it because it does not seem to cause disease or immune system reaction on its own.
So where can I get some of this stuff? Does it come in tablet or gelcaps?
Thanks for posting, this is a fascinating article.
There are two types of cancer reasearch articles.
One is a request for research dollars, and so is the other.
It's all fun and games until the virus mutates.
Bad news- you can only get it from toilet seats in public restrooms.
Using a bullet to kill a bullet...
4-1 you already have it.
So is it the 20 percent that have never been exposed to the virus more prone to cancer?
That means I've GOT it!
This is good news. Hopefully, if the study passes phase3 with a high percentage of success it will be approved ASAP.
Frankly I'd rather see private, state and Federal research dollars go for programs like this than research projects to save endangered species of something like the snail darter or new building projects to be named after some congress critter.
You want private research for other reasons which I will not list if you were being sarcastic.
Saving lives of humans has a higher priority in my book than an endangered animal species or building another presidential library or new office building for GSA to lease out or a congress critter to have named after himself.
I have a personal interest in this and I am biased in my opinion as I have lung cancer stage 3 and I am constantly looking for anything new. Actually, I obtained a copy of this report from MyWay at 4:21 PM 6/21. Yours is a good post. Sorry I was not more specific.
Thank you Infant of Prague.
This could be very good news. Thanks for posting it!
Alright, I can continue my 4 pack a day habit!
This could have huge implications for HIV as well. Having already proven its effectiveness against HPV, HIV seems a logical follow-on candidate.
But then again, maybe the "V" in HIV has been a misnomer...
if you find anyway to get a hold of this virus to take it, please let me know.
I predict this will "go away" and never be heard about again. The ramifications of actually having a cancer "cure" are huge. The drug industry, the medical industry...huge hit. I don't think the gov't wants a cure, or there would already be one.
There is always hope. Viruses are such peculiar things, they could be keys to many revelations. That's something worth praying for, that our researchers find the keys.
Wait until they find out it causes heart disease.
I disagree. The business of treating cancer is huge, and finding a cure would render a large portion of our drug/medical professionals/companies irrelevant. This would result in an enormous negative effect on the economy. My tin foil hat is firmly in place, whether you believe me moronic or not. The bottom line counts.
More like, one is a request for government research grants, and the other is hype to draw in private investment dollars.
But, let's keep in mind it was only a study of 8.
However, what I am waiting for is a gene therapy/drug therapy based on a unusal gene an Italian (I think) family has that essentially makes them immune to heart disease no matter what they do and eat.
It is amazing. I forgot what it is called, but we are still waiting for that to be made into a drug to virtually end completely the heart disease menace.
The cure would be a boon to the economy since every other country would need it, too.
Will do philsfan24. So far I have not come across anything on the internet. I see my oncologist next week and see what I can dig up there.
You may be interested in this, I am participating in a phase 3 double-blind study for a drug currently numbered U-2901 (trade name is Provigil or Modafinil). This study is conducted by Gulf Coast MBCCOP. This drug fights the effects of fatigue caused by various chemotherapy drugs. It has not been approved but it works!
I still have side-effects but now I feel like working in the garden and walking a mile daily. If you need further info contact me via private reply and I'll do the same with this virus study. Have a great day.
It is looking more and more like they will have highly effective treatments against many of the regular forms of cancer very soon.
And with the coming battle over Codex, we might not be able to get them even if it is little more than an ordinary weed or virus.
I'm still reading some real interesting stuff about Graviola, if it turns out it really works, but the drug companies sat on it because they couldn't synthesize it, it would be one of the greatest crimes humanity ever saw.
interesting resource bump
If upwards of 80% of the population has this virus, why is cancer found in such a high percentage of the population (higher than 20%)?
I hope you are correct and I am totally wrong. Perhaps I'm just a bit cynical.
Just as I suspected.
Actually, only about 20 to 25% of people (in the USA) will ever get cancer of any kind in their lifetimes. Also, the article stated that the virus kills cancers of the epithilial cells, which covers many, but not all, types of cancers.
I saw this yesterday.
Is it too good to be true!?
Good to get good news.
"Although the reason why remains unclear, population-based studies have shown that people who carry AAV2 tend not to develop human papillomavirus- (HPV-) associated cervical cancer. In general, AAV2 requires association with a helper virus in order to replicate. When it finds a helper virus, such as HPV, AAV2 disrupts the life cycle of the host and induces apoptosis, a type of cell death.
"one of the ways AAV2 suppresses cancer is by inhibiting the normal process of DNA duplication of human papillomavirus (HPV). HPV is known to lead to cervical cancer. A second way AAV2 suppresses cancer is linked to its ability to slow cell-cycle progression by decreasing cancer cell proliferation rates and causing growth arrest."
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.