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Common virus kills cancer, study finds
Reuters ^ | 6/21/05

Posted on 06/21/2005 3:53:57 PM PDT by Tumbleweed_Connection

A common virus that is harmless to people can destroy cancerous cells in the body and might be developed into a new cancer therapy, U.S. researchers said on Tuesday.

The virus, called adeno-associated virus type 2, or AAV-2, infects an estimated 80 percent of the population.

"Our results suggest that adeno-associated virus type 2, which infects the majority of the population but has no known ill effects, kills multiple types of cancer cells yet has no effect on healthy cells," said Craig Meyers, a professor of microbiology and immunology at the Penn State College of Medicine in Pennsylvania.

"We believe that AAV-2 recognizes that the cancer cells are abnormal and destroys them. This suggests that AAV-2 has great potential to be developed as an anti-cancer agent," Meyers said in a statement.

He said at a meeting of the American Society for Virology that studies have shown women infected with AAV-2 who are also infected with a cancer-causing wart virus called HPV develop cervical cancer less frequently than uninfected women do.

AAV-2 is a small virus that cannot replicate itself without the help of another virus. But with the help of a second virus it kills cells.

For their study, Meyers and colleagues first infected a batch of human cells with HPV, some strains of which cause cervical cancer.

They then infected these cells and normal cells with AAV-2.

After six days, all the HPV-infected cells died.

The same thing happened with cervical, breast, prostate and squamous cell tumor cells.

All are cancers of the epithelial cells, which include skin cells and other cells that line the insides and outsides of organs.

"One of the most compelling findings is that AAV-2 appears to have no pathologic effects on healthy cells," Meyers said.

"So many cancer therapies are as poisonous to healthy cells as they are to cancer cells. A therapy that is able to distinguish between healthy and cancer cells could be less difficult to endure for those with cancer."

AAV-2 is being studied intensively as a gene therapy vector -- a virus modified to carry disease-correcting genes into the body. Gene therapy researchers favor it because it does not seem to cause disease or immune system reaction on its own.


TOPICS: News/Current Events
KEYWORDS: adenovirus; cancer; cancercures; news

1 posted on 06/21/2005 3:53:58 PM PDT by Tumbleweed_Connection
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To: Tumbleweed_Connection; eyespysomething

Wow!


2 posted on 06/21/2005 3:57:49 PM PDT by SittinYonder (Tancredo and I wanna know what you believe)
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To: Tumbleweed_Connection

Fantastic.


3 posted on 06/21/2005 3:59:52 PM PDT by Mr. Mojo
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To: Tumbleweed_Connection

So where can I get some of this stuff? Does it come in tablet or gelcaps?


4 posted on 06/21/2005 4:01:05 PM PDT by Enterprise (Coming soon from Newsweek: "Fallujah - we had to destroy it in order to save it.")
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To: Tumbleweed_Connection

Well, well...BTT...


5 posted on 06/21/2005 4:01:09 PM PDT by Billthedrill
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To: Tumbleweed_Connection

Thanks for posting, this is a fascinating article.


6 posted on 06/21/2005 4:02:06 PM PDT by Judith Anne (Thank you St. Jude for favors granted.)
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To: Tumbleweed_Connection

BTT


7 posted on 06/21/2005 4:06:40 PM PDT by Cindy
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To: Tumbleweed_Connection

There are two types of cancer reasearch articles.

One is a request for research dollars, and so is the other.


8 posted on 06/21/2005 4:18:23 PM PDT by JoeSixPack1
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To: Tumbleweed_Connection

It's all fun and games until the virus mutates.


9 posted on 06/21/2005 4:19:31 PM PDT by fr_freak
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To: Enterprise

Bad news- you can only get it from toilet seats in public restrooms.


10 posted on 06/21/2005 4:20:15 PM PDT by fat city (Julius Rosenberg's soviet code name was "Liberal")
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To: Tumbleweed_Connection

Using a bullet to kill a bullet...


11 posted on 06/21/2005 4:21:32 PM PDT by null and void (2˘)
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To: Enterprise
where can I get some of this stuff?

4-1 you already have it.

12 posted on 06/21/2005 4:22:47 PM PDT by RightWhale (withdraw from the 1967 UN Outer Space Treaty)
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To: Tumbleweed_Connection

Amazing news!


13 posted on 06/21/2005 4:26:22 PM PDT by Lady Jag (Honor - Dignity - Courage - Loyalty)
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To: Tumbleweed_Connection
The virus, called adeno-associated virus type 2, or AAV-2, infects an estimated 80 percent of the population.

So is it the 20 percent that have never been exposed to the virus more prone to cancer?

14 posted on 06/21/2005 5:31:16 PM PDT by dawn53
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To: fat city
"you can only get it from toilet seats in public restrooms."

That means I've GOT it!

15 posted on 06/21/2005 5:56:29 PM PDT by Enterprise (Coming soon from Newsweek: "Fallujah - we had to destroy it in order to save it.")
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To: Tumbleweed_Connection
Thanks for the post Tumbleweed.

This is good news. Hopefully, if the study passes phase3 with a high percentage of success it will be approved ASAP.

Frankly I'd rather see private, state and Federal research dollars go for programs like this than research projects to save endangered species of something like the snail darter or new building projects to be named after some congress critter.

16 posted on 06/21/2005 6:11:25 PM PDT by Luke (CPO, USCG (Ret))
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To: Luke

You want private research for other reasons which I will not list if you were being sarcastic.


17 posted on 06/21/2005 6:13:54 PM PDT by Tumbleweed_Connection (http://hour9.blogspot.com/)
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To: Tumbleweed_Connection
Sorry you think I'm being sarcastic. No... I think there should be a priority in which research dollars are spent - private, state or Federal.

Saving lives of humans has a higher priority in my book than an endangered animal species or building another presidential library or new office building for GSA to lease out or a congress critter to have named after himself.

I have a personal interest in this and I am biased in my opinion as I have lung cancer stage 3 and I am constantly looking for anything new. Actually, I obtained a copy of this report from MyWay at 4:21 PM 6/21. Yours is a good post. Sorry I was not more specific.

18 posted on 06/21/2005 6:40:53 PM PDT by Luke (CPO, USCG (Ret))
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To: Luke

Thank you Infant of Prague.


19 posted on 06/21/2005 6:53:41 PM PDT by CBart95
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To: Tumbleweed_Connection

This could be very good news. Thanks for posting it!


20 posted on 06/21/2005 7:23:57 PM PDT by Yeti
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To: Tumbleweed_Connection

Alright, I can continue my 4 pack a day habit!


21 posted on 06/22/2005 5:34:48 AM PDT by EdHallick ("KHAAAAAAAAAAAAAAAAAN!" - Capt. James T. Kirk)
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To: Lady Jag

This could have huge implications for HIV as well. Having already proven its effectiveness against HPV, HIV seems a logical follow-on candidate.

But then again, maybe the "V" in HIV has been a misnomer...

R3


22 posted on 06/22/2005 6:01:07 AM PDT by RedRightReturn
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To: Luke

if you find anyway to get a hold of this virus to take it, please let me know.


23 posted on 06/22/2005 7:54:03 AM PDT by philsfan24
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To: Tumbleweed_Connection

I predict this will "go away" and never be heard about again. The ramifications of actually having a cancer "cure" are huge. The drug industry, the medical industry...huge hit. I don't think the gov't wants a cure, or there would already be one.


24 posted on 06/22/2005 7:58:00 AM PDT by I'm ALL Right! (WWW.TEACH-YOUR-KIDS.COM)
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To: I'm ALL Right!
I nominate your post for the Most Moronic Post of the Daytm

by this "logic", everything that can be discovered has already been discovered, and cures for all diseases already exist - thye've just been suppressed by the government-millitary-industrial-pharmeceutical complex!
25 posted on 06/22/2005 9:12:26 AM PDT by CzarChasm (My opinion. No charge.)
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To: RedRightReturn
This could have huge implications for HIV as well. Having already proven its effectiveness against HPV.

There is always hope. Viruses are such peculiar things, they could be keys to many revelations. That's something worth praying for, that our researchers find the keys.

26 posted on 06/22/2005 9:31:52 AM PDT by Lady Jag (Honor - Dignity - Courage - Loyalty)
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To: Tumbleweed_Connection
A common virus that is harmless to people can destroy cancerous cells in the body

Wait until they find out it causes heart disease.

27 posted on 06/22/2005 9:33:13 AM PDT by dirtboy (Drool overflowed my buffer...)
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To: CzarChasm

I disagree. The business of treating cancer is huge, and finding a cure would render a large portion of our drug/medical professionals/companies irrelevant. This would result in an enormous negative effect on the economy. My tin foil hat is firmly in place, whether you believe me moronic or not. The bottom line counts.


28 posted on 06/22/2005 9:40:42 AM PDT by I'm ALL Right!
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To: JoeSixPack1
There are two types of cancer reasearch articles. One is a request for research dollars, and so is the other.

More like, one is a request for government research grants, and the other is hype to draw in private investment dollars.

29 posted on 06/22/2005 9:43:27 AM PDT by kevkrom (“It’s good to remember whom people turn to when they’re desperate — and it ain’t Kofi Annan.”)
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To: Tumbleweed_Connection; All

Sounds great.

But, let's keep in mind it was only a study of 8.

However, what I am waiting for is a gene therapy/drug therapy based on a unusal gene an Italian (I think) family has that essentially makes them immune to heart disease no matter what they do and eat.

It is amazing. I forgot what it is called, but we are still waiting for that to be made into a drug to virtually end completely the heart disease menace.


30 posted on 06/22/2005 10:06:17 AM PDT by rwfromkansas (http://www.xanga.com/home.aspx?user=rwfromkansas)
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To: I'm ALL Right!

The cure would be a boon to the economy since every other country would need it, too.


31 posted on 06/22/2005 10:08:57 AM PDT by rwfromkansas (http://www.xanga.com/home.aspx?user=rwfromkansas)
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To: Conservative4Life

ping


32 posted on 06/22/2005 10:12:11 AM PDT by Trillian
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To: philsfan24
if you find anyway to get a hold of this virus to take it, please let me know.

Will do philsfan24. So far I have not come across anything on the internet. I see my oncologist next week and see what I can dig up there.

You may be interested in this, I am participating in a phase 3 double-blind study for a drug currently numbered U-2901 (trade name is Provigil or Modafinil). This study is conducted by Gulf Coast MBCCOP. This drug fights the effects of fatigue caused by various chemotherapy drugs. It has not been approved but it works!

I still have side-effects but now I feel like working in the garden and walking a mile daily. If you need further info contact me via private reply and I'll do the same with this virus study. Have a great day.

33 posted on 06/22/2005 10:48:10 AM PDT by Luke (CPO, USCG (Ret))
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To: I'm ALL Right!
I didn't say you were moronic, i said your post was moronic.

perhaps your tinfoil hat is on a little too tight - assuming your presmise is true, which i doubt, but assuming that it is true just for fun, how much bigger would be a market for cancer cures and preventatives - which many people would pay a premium for - as opposed to the current market for questionable treatments that don't cure?

Imagine the market value of a 'cancer vaccine', for example...
34 posted on 06/22/2005 12:30:33 PM PDT by CzarChasm (My opinion. No charge.)
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To: I'm ALL Right!
Free enterprise will take over here. The first company who can market this, assuming it works, will be the largest company in their market. The fact that this has been made public will keep it from being suppressed by anyone. Hell, we FReepers know the name of the virus and what it may do. Now any person with the right skills can look into this.

If this is in fact a cure, it's out of the bottle and won't be easily put back in. If there is real promise to this expect a race to use this, not suppression.
35 posted on 06/22/2005 5:12:36 PM PDT by KoRn
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To: Kelly_2000

AAV-2 Ping!


36 posted on 06/22/2005 5:50:24 PM PDT by Domestic Church (AMDG...)
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To: Tumbleweed_Connection

It is looking more and more like they will have highly effective treatments against many of the regular forms of cancer very soon.

And with the coming battle over Codex, we might not be able to get them even if it is little more than an ordinary weed or virus.

I'm still reading some real interesting stuff about Graviola, if it turns out it really works, but the drug companies sat on it because they couldn't synthesize it, it would be one of the greatest crimes humanity ever saw.


37 posted on 06/22/2005 5:56:30 PM PDT by djf (Government wants the same things I do - MY guns, MY property, MY freedoms!)
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To: djf

interesting resource bump


38 posted on 06/22/2005 6:02:21 PM PDT by rbmillerjr
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To: Tumbleweed_Connection

Holy cow!


39 posted on 06/22/2005 6:03:28 PM PDT by abigailsmybaby
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To: fr_freak

If upwards of 80% of the population has this virus, why is cancer found in such a high percentage of the population (higher than 20%)?


40 posted on 06/22/2005 6:37:55 PM PDT by MHGinTN (If you can read this, you've had life support from someone. Promote life support for others.)
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To: KoRn

I hope you are correct and I am totally wrong. Perhaps I'm just a bit cynical.


41 posted on 06/22/2005 6:47:45 PM PDT by I'm ALL Right!
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To: Cincinatus' Wife; Berosus; blam; dervish; Do not dub me shapka broham; Ernest_at_the_Beach; ...
Ping!
42 posted on 06/22/2005 10:38:28 PM PDT by SunkenCiv (FR profiled updated Tuesday, May 10, 2005. Fewer graphics, faster loading.)
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To: Tumbleweed_Connection

Just as I suspected.


43 posted on 06/22/2005 10:44:20 PM PDT by Lancey Howard
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To: MHGinTN
If upwards of 80% of the population has this virus, why is cancer found in such a high percentage of the population (higher than 20%)?

Not sure. But a key to that question, assuming that this AAV-2 does kill cancer cells, may be in the quote from the article below:

AAV-2 is a small virus that cannot replicate itself without the help of another virus. But with the help of a second virus it kills cells.

They don't mention the other viruses. Trade secret? Anyway, maybe most people lack one of the crucial partner viruses.
44 posted on 06/22/2005 10:59:21 PM PDT by fr_freak
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To: Brad's Gramma

fyi


45 posted on 06/22/2005 11:00:12 PM PDT by Ernest_at_the_Beach
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To: MHGinTN; fr_freak
If upwards of 80% of the population has this virus, why is cancer found in such a high percentage of the population (higher than 20%)?

Actually, only about 20 to 25% of people (in the USA) will ever get cancer of any kind in their lifetimes. Also, the article stated that the virus kills cancers of the epithilial cells, which covers many, but not all, types of cancers.

46 posted on 06/22/2005 11:18:15 PM PDT by rmh47 (Go Kats! - Got Seven? [NRA Life Member])
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To: SunkenCiv

I saw this yesterday.

Is it too good to be true!?

Good to get good news.


47 posted on 06/23/2005 12:52:26 AM PDT by Cincinatus' Wife
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To: fr_freak

"Although the reason why remains unclear, population-based studies have shown that people who carry AAV2 tend not to develop human papillomavirus- (HPV-) associated cervical cancer. In general, AAV2 requires association with a helper virus in order to replicate. When it finds a helper virus, such as HPV, AAV2 disrupts the life cycle of the host and induces apoptosis, a type of cell death.

"one of the ways AAV2 suppresses cancer is by inhibiting the normal process of DNA duplication of human papillomavirus (HPV). HPV is known to lead to cervical cancer. A second way AAV2 suppresses cancer is linked to its ability to slow cell-cycle progression by decreasing cancer cell proliferation rates and causing growth arrest."

http://www.eurekalert.org/pub_releases/2005-06/ps-shv062105.php


48 posted on 06/23/2005 1:06:24 AM PDT by endthematrix (Thank you US armed forces, for everything you give and have given!)
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