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To: tallhappy

"If you actually knew anything about molecular evolution or biology and acually had read the article in the recent Science concerning the Chimp's repeating element organization you'd know that the talk origins article you are fond of citing is dreadfully out of date and never has been really accurate."

I have and I understand it, would you care to elaborate?


48 posted on 09/26/2005 8:25:27 AM PDT by furball4paws (One of the last Evil Geniuses, or the first of their return.)
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To: furball4paws

***I have and I understand it, would you care to elaborate?***

Sorry. It's Nature, not Science. My mistake. Interesting you have it in Science... :)

Nonetheless, I refer you to Cheng et al, Nature: 88 2005.

Here's the full ref and abstract.

_____

Nature. 2005 Sep 1;437(7055):88-93.

A genome-wide comparison of recent chimpanzee and human segmental duplications.

Cheng Z, Ventura M, She X, Khaitovich P, Graves T, Osoegawa K, Church D, DeJong
P, Wilson RK, Paabo S, Rocchi M, Eichler EE.

Howard Hughes Medical Institute, Department of Genome Sciences, University of
Washington School of Medicine, 1705 NE Pacific Street, Seattle, Washington
98195, USA.

We present a global comparison of differences in content of segmental
duplication between human and chimpanzee, and determine that 33% of human
duplications (> 94% sequence identity) are not duplicated in chimpanzee,
including some human disease-causing duplications. Combining experimental and
computational approaches, we estimate a genomic duplication rate of 4-5
megabases per million years since divergence. These changes have resulted in
gene expression differences between the species. In terms of numbers of base
pairs affected, we determine that de novo duplication has contributed most
significantly to differences between the species, followed by deletion of
ancestral duplications. Post-speciation gene conversion accounts for less than
10% of recent segmental duplication. Chimpanzee-specific hyperexpansion (> 100
copies) of particular segments of DNA have resulted in marked quantitative
differences and alterations in the genome landscape between chimpanzee and
human. Almost all of the most extreme differences relate to changes in
chromosome structure, including the emergence of African great ape subterminal
heterochromatin. Nevertheless, base per base, large segmental duplication events
have had a greater impact (2.7%) in altering the genomic landscape of these two
species than single-base-pair substitution (1.2%).


62 posted on 09/26/2005 10:09:53 AM PDT by tallhappy (Juntos Podemos!)
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