[misterrob]

No they wouldn't. Nuking Israel would mean:

a) Death of Palestinians

b) Death of Hizbollah Allies

c) Death of Syrian Allies

and the end of Iran's theocracy. W would retaliate in kind with tactical nukes.

Holding nukes gives them some extra chips in case of an invasion.

[thoughtomator]

Unless they don't believe their own rhetoric (unlikely, as that rhetoric is perfectly consistent with their observed behavior), none of those things would matter to them. Muslims don't care if they die if they think they are getting their virgins in the process.

[Das Outsider]

W would retaliate in kind with tactical nukes.

So let me get this straight:

Iran uses nuclear weapons against Israel. The U.S. responds with tactical nuclear strikes, right? But when Tom Tancredo suggested that, in the event of multiple nuclear strikes inside the U.S. by Islamic terrorists, that we should nuke Mecca, he was branded a lunatic, far-right extremist, etc.--by his own party!

[ASA Vet]

All your assumptions have one flaw.

They assume sanity.

[Fred Hayek]

They don't give a rat's patoot about the Palestinians. The Pali's are just expendable cannon fodder.