I don't believe the Israeli's can fly to Iran and back without refueling. They would need to refuel a couple of times if not three times.
IIRC, the Israelis have KC-135s. However, I think any attack on Iran will be a US action. Attacking and destroying Iran's nuclear capabilities is within Israeli capabilities. But that will only lead to Iranian retaliatory attacks unless the United States also participates to destroy the Iranian armed forces' and the Revolutionary Guard's offensive capabilities. Doing this would require a concerted air campaign lasting weeks or months. The United States is the only military power capable of doing that job.