By gum number one! The Borgs are gradually reducing my hairline!!!
AHHHH!
"Well there are always hats!"
Posted on 05/08/2006 2:57:12 PM PDT by Pharmboy
A number of studies have shown that restricting calories increases the lifespan of animals, but the biological basis for this has remained elusive. A new report hints that growth hormone, as well as insulin, are key factors in the life-extending effects of calorie restriction.
"The implication ... for pharmaceutical development would be that the signaling pathways of growth hormone and insulin may be logical targets for development of anti-aging medicine," Dr. Andrezej Bartke from Southern Illinois University in Springfield told Reuters Health.
"Although it would be irresponsible to recommend that healthy people start using anti-diabetic drugs," said Bartke, "it is reasonable to suggest that treatment(s) causing an improvement in insulin sensitivity combined with modest reduction in insulin release would reduce risk of age-related disease and likely also delay aging."
Bartke's team tested whether growth hormone and insulin are tied to the life-extending effects of calorie restriction in a series of experiments with normal mice and mutant mice deficient in growth hormone.
The mutant mice do not express the receptor for growth hormone (and are therefore growth hormone resistant), have profoundly suppressed insulin levels, and are known to live longer and age more slowly than normal mice, the researchers note in Proceedings of the National Academy of Sciences.
As expected, the team observed that restricting food increases longevity in normal healthy mice. Reduced feeding increased lifespan by about 19 percent in normal male mice and by about 28 percent in normal female mice.
However, in sharp contrast to its effects in normal mice, calorie restriction failed to increase lifespan in mutant mice lacking growth hormone receptor. "The present findings show that growth hormone resistant mice fail to respond normally to calorie restriction, a very effective life-extending intervention," Bartke said.
"The key implication of this study is that growth hormone receptor and thus presumably the normal, physiological actions of growth hormone are important in regulation of aging and life span," Bartke said.
The team also found that calorie restriction for 12 months improves insulin sensitivity in normal mice but fails to further enhance the "remarkable insulin sensitivity" in growth hormone knockout mice.
This finding, Bartke said, "supports our hypothesis that increased sensitivity to the actions of insulin is a very important and perhaps the key mechanism of delayed aging and prolonged longevity in growth hormone deficient and growth hormone resistant mice."
SOURCE: PNAS, May 16, 2006.
Pinging just for the bio interested...no need to ping your lists.
I've learned one can live well past 100 by adopting a vegetarian lifestyle including juicing and low-caloric intake.
By gum number one! The Borgs are gradually reducing my hairline!!!
AHHHH!
"Well there are always hats!"
Or "Heard"?
This is what Dr. Sears (inventor of the zone diet) has been saying for over a decade.
Why would you want to live past 100 when the Kennedy infection in this country seems endless? Do you realy want to be 100 only to hear "And Ted Patrick Kennedy the IIIIIth has been elected!"
Even if you get hit by a truck?
Yeah but who wants to live to 100 if you can't eat a big fat juicy STEAK!
Acromegaly, a medical condition involving excess growth hormone secretion, does indeed affect the ears.
ESPECIALLY if you get hit by a truck! In the impact, you steal the truck's lifeforce.
Not me. Between now and the great beyond, I plan to have at least two big fat juicy steaks. Probably more.
Learned. The science is pretty good, as far as I can tell.
I'm totally convinced that HGH is the key to slowing aging. I've been taking a combo of L-Arganine & L-Lysine (combo stimulates the natural production of HGH) for 15 years now with amazing results.
Cool, man!
Hi honey. Thanks for pinging me to this thread :D
Who are the products manufactured by?
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