His supporters will have to find another candidate, someone like, hmm, Newt.
I think, what with the DriveBys, Newt's Peter Point is Veep. Imagine the wreckage he could cause there, presiding over the Senate. Somehow, I'd guess he'd become a little more "hands on" than precedented protocol would dictate. And he has some scores to settle, too.
Not to mention his ideas, ideals, and ability to flak political points not having to be Chief Exec.