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Alzheimer's sufferers can regain memories
UK Telegraph ^ | April 30, 2007 | Roger Highfield

Posted on 4/30/2007, 12:24:43 PM by syriacus

The victims of Alzheimer's could in theory recover their "lost" memories, according to a study which overturns conventional wisdom.

The study suggests that long-term memories are not destroyed by dementia but made inaccessible.

The insight has come from studies of mice whose brains lost a large number of nerve cells due to neuro-degeneration.

They regained long-term memories and the ability to learn after their surroundings were enriched with toys and other sensory stimuli, according to the study published today in Nature.

(Excerpt) Read more at telegraph.co.uk ...


TOPICS: Miscellaneous
KEYWORDS: alzheimers; hdacinhibitor; hhmi; lihueitsai
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1 posted on 4/30/2007, 12:24:44 PM by syriacus
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To: syriacus
Boredom link to Alzheimer's disease
2 posted on 4/30/2007, 12:28:29 PM by syriacus (Imus is gone because he flustered Schumer by telling the world he hadn't visited Walter Reed.)
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To: syriacus

One poor soul I know, who suffers from the disease - is far better off NOT remembering.....

I still suspect that his dementia — provides a peaceful respite from his nightmares.

He is at peace for the first time in nearly 40 years..


3 posted on 4/30/2007, 12:29:17 PM by river rat (Semper Fi - You may turn the other cheek, but I prefer to look into my enemy's vacant dead eyes.)
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To: syriacus

Does that mean they can’t hide their own Easter eggs anymore?


4 posted on 4/30/2007, 12:29:46 PM by Puppage (You may disagree with what I have to say, but I shall defend to your death my right to say it)
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To: river rat

Now that’s sad.....poor guy...


5 posted on 4/30/2007, 12:30:18 PM by Fawn (Achmed the Dead Terrorist--> http://youtube.com/watch?v=2QXQFTEBqNE)
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To: syriacus
Reversing Alzheimer's memory loss may be possible
6 posted on 4/30/2007, 12:30:32 PM by syriacus (Imus is gone because he flustered Schumer by telling the world he hadn't visited Walter Reed.)
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To: river rat

A study such as this, if true, could also lead to possible research and cures for “erasing” un-wanted bad memories...........


7 posted on 4/30/2007, 12:32:43 PM by Red Badger (My gerund got caught in my diphthong, and now I have a dangling participle...............)
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To: syriacus
They regained long-term memories and the ability to learn after their surroundings were enriched with toys and other sensory stimuli

At last, an excuse to acquire more toys!

Not to mention more, ahem, "sensory stimuli."

8 posted on 4/30/2007, 12:37:19 PM by blau993
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To: river rat
One poor soul I know, who suffers from the disease - is far better off NOT remembering

A friend's mother became much less irritable, than she had been for decades, as her Alzheimer's deepened.

9 posted on 4/30/2007, 12:37:21 PM by syriacus (Imus is gone because he flustered Schumer by telling the world he hadn't visited Walter Reed.)
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To: Fawn

I’m not so sure.....that it’s all sadness in his case.

He appears a lot more relaxed now, than before the disease progressed to the current point..
He certainly smiles a lot more - which makes him look a LOT more like we remembered him..
When the inevitable “war stories” begin to circulate after a few adult beverages at our regular reunions or get togethers — he seems to have no recollection.....

From my observation, it is a LOT harder and sadder for his wife, children and grandchildren - because they have lost one hell of a man. Now, he can’t be out of their sight for fear of him wandering off or hurting himself doing the simplest task...

The was one hell of a man - one whom we could all rely upon...


10 posted on 4/30/2007, 12:38:50 PM by river rat (Semper Fi - You may turn the other cheek, but I prefer to look into my enemy's vacant dead eyes.)
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To: Red Badger

To date, the ONLY erasers I’ve seen that worked were, swallowing the barrel of a Model 1911, drink or drugs...

Most prefer to deal with them....and stay the hell out of “professional” offices..

Haven’t you noticed how many old Grunts are up at 3 or 4 in the morning talking to folks at FreeRepublic?


11 posted on 4/30/2007, 12:45:38 PM by river rat (Semper Fi - You may turn the other cheek, but I prefer to look into my enemy's vacant dead eyes.)
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To: river rat

Et tu?..........


12 posted on 4/30/2007, 12:51:36 PM by Red Badger (My gerund got caught in my diphthong, and now I have a dangling participle...............)
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To: Red Badger

Dawn is breaking now in Kalifornicate...
Think I’ll get some sleep.


13 posted on 4/30/2007, 12:59:41 PM by river rat (Semper Fi - You may turn the other cheek, but I prefer to look into my enemy's vacant dead eyes.)
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To: river rat

What about Tony Orlando?.........


14 posted on 4/30/2007, 1:07:51 PM by Red Badger (My gerund got caught in my diphthong, and now I have a dangling participle...............)
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To: syriacus
Regaining lost memories, By: Will Dunham

Mon Apr 30, 2007 7:49 AM EDT

WASHINGTON (Reuters) - Mental stimulation and drug treatment may help people with brain ailments such as Alzheimer's disease regain seemingly lost memories, according to research published on Sunday.

Scientists used two methods to reverse memory loss in mice with a condition like Alzheimer's -- placing them in sort of a rodent Disneyland to stimulate their brains, and also using a type of drug that encourages growth of brain nerve cells. [excerpt]


15 posted on 4/30/2007, 1:20:32 PM by syriacus (Imus is gone because he flustered Schumer by telling the world he hadn't visited Walter Reed.)
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To: syriacus

One of the researchers

Neuroscientist Li-Huei Tsai of the Howard Hughes Medical Institute and the Massachusetts Institute of Technology


16 posted on 4/30/2007, 1:23:41 PM by syriacus (Imus is gone because he flustered Schumer by telling the world he hadn't visited Walter Reed.)
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To: syriacus

from:
http://www.dailyindia.com/show/137483.php/Boffins-restore-lost-memories-by-natural-rewiring-of-brain-cells

The researchers then induced histone-tail acetylations that could help pick up long-term memory. Tsai’s team targeted enzymes called HDACs, which prevent acetylation of histones.

The researchers took mice that had lost long-term memory and injected them with a drug that inhibited HDACs. When tested, the team found that these mice were better able to find the platform in the water.

Tsai said that HDAC inhibitors seem to cause naturally the rewiring of neurons.


17 posted on 4/30/2007, 1:27:30 PM by syriacus (Imus is gone because he flustered Schumer by telling the world he hadn't visited Walter Reed.)
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To: syriacus

http://www.allaboutmedicalsales.com/overviews/histone-deacetylase-inhibitors-lead-discovery-271003.html

Histone deacetylase inhibitors: Redefining pharmaceutical approaches to the treatment of cancer
(Publication date: September 2002)[snip]

Despite the youth of the field of HDAC inhibitors, an impressive body of data describes the ability of these molecules to modulate a wide variety of cellular functions, including cell differentiation, cell cycle progression, apoptosis, cytoskeletal modifications, and angiogenesis. A major aim of the present report was to overview this body of evidence and to demonstrate how this activity translates to therapeutic efficacy in models of cancer. [snip]

The most exciting opportunities for HDAC inhibitors are, however, on the horizon. These opportunities are related in part to the requirement of HDACs to complex with other regulatory proteins in order to modulate transcription. [excerpt]


18 posted on 4/30/2007, 1:34:52 PM by syriacus (Imus is gone because he flustered Schumer by telling the world he hadn't visited Walter Reed.)
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To: syriacus
Histone deacetylase [wikipedia]
19 posted on 4/30/2007, 1:39:01 PM by syriacus (Imus is gone because he flustered Schumer by telling the world he hadn't visited Walter Reed.)
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To: syriacus

It occurs to me - hiw can you tell that a mouse has lost long term memory?


20 posted on 4/30/2007, 1:42:50 PM by statered ("And you know what I mean.")
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