[Canticle_of_Deborah]

First, Depo-Provera often did the same thing and started being used nearly thirty years ago. It has fallen into disfavor, partly because of calcium losses.

This is the first thing that came to my mind about this new drug - osteoporosis.

[RockinRight]

From what I hear, it creates menopause-like symptoms - hot flashes, lack of sexual desire, etc.

Almost makes it kinda pointless side effects aside.