You big softy. If Israel gets attacked with a nuke they should immediately bomb all Islamic “holy cities”, regardless of affiliation (and with the obvious exception of Jerusalem, which as you say should be extensively remodelled).
The Sunnis would be cheering a Shiite attack - let them suffer for it.
Look for Russia and the US to step in if Israel tries the Samson option. Non the less if Israel gets a few nukes then all Muslim holy cites must be turned to glass. This must be the first move. Then other Persian and Arab targets are wasted