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Chemical in red wine, fruits and vegetables stops cancer, heart disease, depending on the dose
Federation of American Societies for Experimental Biology ^ | October 30, 2007 | Unknown

Posted on 10/30/2007, 1:30:25 PM by decimon

Research in the FASEB Journal lays the groundwork for safe, new cancer therapy

The next cancer drug might come straight from the grocery store, according to new research published in the November 2007 issue of The FASEB Journal. In the study, French scientists describe how high and low doses of polyphenols have different effects. Most notably, they found that very high doses of antioxidant polyphenols shut down and prevent cancerous tumors by cutting off the formation of new blood vessels needed for tumor growth. Polyphenols are commonly found in red wine, fruits, vegetables, and green tea.

At relatively low doses, the French researchers found that the same polyphenols play a beneficial role for those with diseased hearts and circulatory systems by facilitating blood vessel growth. The amount of polyphenols necessary for this effect was found to be the equivalent of only one glass of red wine per day or simply sticking to a healthy diet of fruits and vegetables containing polyphenols. This diet is known as the “Mediterranean Diet.” This study also adds to a growing body of research showing dose-dependent relationships for many types of commonly used compounds. For instance, research published in the October 2006 issue of The FASEB Journal shows that aspirin, through different mechanisms, also has a dose-dependent relationship for heart disease and cancer.

"When it comes to finding treatments for complex diseases, the answers are sometimes right there waiting to be discovered in unexpected places like the produce aisles and wine racks of the nearest store,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. “But it takes modern science to isolate the pure compound, test it in the lab, and to go on from there to find new agents to fight disease.”

According to the authors, the amount of polyphenols necessary to obtain an anti-cancer effect is the equivalent of drinking about a bottle of red wine each day. This amount of daily alcohol consumption obviously is unhealthy, but the research suggests that polyphenols extracted from plants or red wine could be converted into a pill that is highly likely to be safe. Such a pill also would be relatively easy and inexpensive to create and deliver.

“The use of plant polyphenols as therapeutic tools presents important advantages,” said Daniel Henrion, senior author of the study, “because they have a good safety profile, a low cost and they can be obtained everywhere on the planet.”

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The FASEB Journal (www.fasebj.org) is published by the Federation of American Societies for Experimental Biology (FASEB) and is consistently ranked among the top three biology journals worldwide by the Institute for Scientific Information. FASEB comprises 21 nonprofit societies with more than 80,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB advances biological science through collaborative advocacy for research policies that promote scientific progress and education and lead to improvements in human health.


TOPICS: Culture/Society; Miscellaneous; News/Current Events; Technical
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1 posted on 10/30/2007, 1:30:27 PM by decimon
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To: decimon
Let's see, a French team of scientists discover another use for red wine.

"A bottle a day cures cancer" they proclaim!

Stuff like this is why they invented the FDA (Food and Drug Administration).

Now for some lengthy testing.

2 posted on 10/30/2007, 1:38:10 PM by muawiyah
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To: muawiyah
Now for some lengthy testing.

I volenteer.

3 posted on 10/30/2007, 1:38:56 PM by CougarGA7 (I'm supporting a Conservative not a RINO http://www.gohunter08.com/)
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To: decimon

Hopefully Tomatoes have a lot, with the amount of Pasta I eat, hopefully it makes a difference.


4 posted on 10/30/2007, 1:41:06 PM by Catholic Canadian ( I love Stephen Harper!)
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To: CougarGA7

I know I always feel better after a couple glasses of wine.


5 posted on 10/30/2007, 1:42:09 PM by taxcontrol
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To: CougarGA7

I’ll volunteer


6 posted on 10/30/2007, 1:45:40 PM by wastedyears (One Marine vs. 550 consultants. Sounds like good odds to me.)
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To: muawiyah
Let's see, a French team of scientists discover another use for red wine.

Not really. They say the requisite amount from wine is impractical but the polyphenols in pill form is viable.

7 posted on 10/30/2007, 1:46:21 PM by decimon
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To: Catholic Canadian
Hopefully Tomatoes have a lot, with the amount of Pasta I eat...

If you don't mind looking like Sydney Greenstreet then that could be a good program to follow.

8 posted on 10/30/2007, 1:49:07 PM by decimon
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To: decimon
But it takes modern science to isolate the pure compound, test it in the lab

There are many chemicals that will kill cancer in a test tube. Until they actually succeed in human trials, this article is just advertising hype for the wine industry.

9 posted on 10/30/2007, 1:50:00 PM by aimhigh
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To: decimon

Polly Feenman filled five pill bottles with polyphenols in pill form.


10 posted on 10/30/2007, 1:52:43 PM by Drawsing (The fool shows his annoyance at once. The prudent man overlooks an insult. (Proverbs 12:16))
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To: aimhigh

En Vino Veri Tas.


11 posted on 10/30/2007, 1:52:52 PM by massgopguy (I owe everything to George Bailey)
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To: decimon
the amount of polyphenols necessary to obtain an anti-cancer effect is the equivalent of drinking about a bottle of red wine each day

The Park Bench Diet


12 posted on 10/30/2007, 1:57:23 PM by montag813
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To: decimon

This article fails to mention that cocoa also contains polyphenols, and even better compounds that prevent cancer and also strengthen blood vessels, helping to prevent strokes, heart attacks and aneurysms.


13 posted on 10/30/2007, 1:58:44 PM by montag813
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To: montag813

The Italians eat Nutella on their bread in the morning(I think that’s the correct spelling). I have been using this lovely chocolate spread for years. I also drink a glass red wine at lunch then 1 or 2 again at dinner.

Fabulous!


14 posted on 10/30/2007, 2:06:53 PM by Lobbyist (I want my American dream!!!!)
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To: montag813

...and my wife goes, “eeewwwww” when I dip my Oreo in my cabernet. Hah! I was just ahead of my time!


15 posted on 10/30/2007, 2:10:25 PM by jagusafr ("Bugs, Mr. Rico! Zillions of 'em!" - Robert Heinlein)
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To: Catholic Canadian
I've heard that tomatoes do, but the benefit is greatest if the tomato is cooked for some reason...releases more of the antioxidant or some such.

Too bad for me, because I despise tomatoes in pretty much any form.

16 posted on 10/30/2007, 2:10:44 PM by ErnBatavia (...forward this to your 10 very best friends....)
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To: decimon

“Polyphenols are commonly found in red wine, fruits, vegetables, and green tea.”

All part of my daily regimen. Here’s hoping!


17 posted on 10/30/2007, 2:16:45 PM by timsbella (Mark Steyn for Prime Minister of Canada! (Steve's won my vote in the meantime))
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To: montag813

Perhaps the best source available in health stores is quercetin. It is usually sold in combination with Vitamin C.


18 posted on 10/30/2007, 2:20:37 PM by Melchior
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To: Lobbyist

My son LOVES NUTELLA. Agree completely.


19 posted on 10/30/2007, 2:20:38 PM by timsbella (Mark Steyn for Prime Minister of Canada! (Steve's won my vote in the meantime))
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To: decimon

You can get the same amount of polyphenols from drinking grape juice without the benefits/hazards of consuming the alcohol. Blackberry juice is even better.


20 posted on 10/30/2007, 3:01:53 PM by whipitgood (Let's burn some MEXICAN flags!)
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