Yes. 95% of the time it's the euphemism used for either "suicide" or "too addicted to depressants to control oneself". The other 5% is real dosage error, stupid binging/mixing contraindicated drugs or body chemistry malreaction. Even then, it is almost entirely avoidable with a microgram of thought about what you are putting in your body.
But we still don’t KNOW, and until we do, I think we should reserve judgement.