Oprah and her PR will re-tool him.
However, they will never erase the fact that he is half-black, half-white and a Muslim.
Still, none of that matters (and he's hardly a Moslem anyway ~ that was his baby-daddy and step daddy ~ Momma was an atheist). What does count is that among Democrats there's this 20% to 30% bunch who will not now nor ever vote for anyone who is not, to their understanding, "pure white", whatever that might be.
Best bet for Republicans to screw up the Democrats is to go to the Dem primaries and vote for Obama.
Presuming Obama can grab the nomination and run in the Fall, that gives the Republican opponent just about a landslide's difference in the popular vote since those Democrats who won't vote for Obama will either scratch (not vote for President), or actually vote for the Republican.
I see it as an insurmountable advantage for the Republicans.