I’ll go back to the ages of the children. If the youngest is still in infancy, it could be a post partum depression. For alot of women, their yearly gyne appointment is their only medical care. Ob/gyns are trained in defining PP and clinical depression. Regulating her brain chemistry could go along way to treating her other problems.
Ditto from me.
Well good luck with the toidy!!! Sadly, I have experience with faulty plumbing as well.