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To: allmendream; MrB; GourmetDan; metmom

==I was just looking for it....

Did you find anything yet? Unless we are talking about two different subjects, your contention that epigenetics has nothing to do with heat stress proteins is clearly in error. Here’s another paper on the crucial role epigenetics plays with respect to heat stress proteins:

Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution

Morphological alterations have been shown to occur in Drosophila melanogaster when function of Hsp90 (heat shock 90-kDa protein 1, encoded by Hsp83) is compromised during development1. Genetic selection maintains the altered phenotypes in subsequent generations1. Recent experiments have shown, however, that phenotypic variation still occurs in nearly isogenic recombinant inbred strains of Arabidopsis thaliana 2. Using a sensitized isogenic D. melanogaster strain, iso-Kr If-1, we confirm this finding and present evidence supporting an epigenetic mechanism for Hsp90’s capacitor function, whereby reduced activity of Hsp90 induces a heritably altered chromatin state. The altered chromatin state is evidenced by ectopic expression of the morphogen wingless in eye imaginal discs and a corresponding abnormal eye phenotype, both of which are epigenetically heritable in subsequent generations, even when function of Hsp90 is restored. Mutations in nine different genes of the trithorax group that encode chromatin-remodeling proteins also induce the abnormal phenotype. These findings suggest that Hsp90 acts as a capacitor for morphological evolution through epigenetic and genetic mechanisms.

http://www.nature.com/ng/journal/v33/n1/abs/ng1067.html


491 posted on 08/15/2008 2:42:05 PM PDT by GodGunsGuts
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To: GodGunsGuts
I didn't say epigenetics had nothing to do with HEAT SHOCK PROTEINS (transcription factors that respond to heat stress). Get a clue.

I said epigenetics had nothing to do with the mutation and natural selection of a protein for heat tolerance such as the xylenase example I provided.

How would epigenetics (which turns on and off genes by DNA methylation) account for a DIFFERENT protein being produced? Can you answer that?

How could methylation of DNA lead to a three amino acid substitution in a xylenase enzyme that makes it function at higher temperatures?

494 posted on 08/15/2008 2:46:00 PM PDT by allmendream (If "the New Yorker" makes a joke, and liberals don't get it, is it still funny?)
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