I am a Type II and Actos is more dangerous than Metformin or Glyburide. Although I just started Byetta and hope to reduce or eliminate some of the others.
Make sure you also read: http://www.freerepublic.com/focus/f-news/2354967/posts
At this stage in their development these drugs may be a bit clunky and could precipitate MIs.
Think of what this means a few decades down the line when metaformin-like drugs can be fine-tuned to be administered daily to ward of a wide variety of cancers.