Thanks Waffle! I really need to know why I have been subscribed for simvastin.
Must be that you understand your post, yet the unwashed have no idea what its about!
So I'll repost your article and hope that you can tell me:
1. What it means, and,
2. What it means"
Thanks! - a Simvastin client!
-------------------------------------------------------------------------------- Journal of Lipid Research, Vol. 50, 2095-2102, October 2009 Copyright © 2009 by American Society for Biochemistry and Molecular Biology
Differential effects of simvastatin and pravastatin on expression of Alzheimer’s disease-related genes in human astrocytes and neuronal cells Weijiang Dong1,*,, Simona Vuletic1,* and John J. Albers2,* * Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Department of Medicine, Seattle 98109, WA Xi’an Jiaotong University School of Medicine, Department of Human Anatomy and Histology and Embryology, Xi’an 710061, People’s Republic of China
2 To whom correspondence should be addressed. e-mail: jja@u.washington.edu
Inhibitors of HMG-CoA reductase (statins) are widely used medications for reduction of cholesterol levels. Statin use significantly reduces risk of cardiovascular disease but has also been associated with lower risk of other diseases and conditions, including dementia. However, some reports suggest that statins also have detrimental effects on the brain. We provide evidence that simvastatin and pravastatin have significantly different effects on expression of genes related to neurodegeneration in astrocytes and neuroblastoma (SK-N-SH) cells in culture. Simvastatin significantly reduced expression of ABCA1 in astrocytes and neuroblastoma cells (by 79% and 97%, respectively; both P < 0.001). Pravastatin had a similar but attenuated effect on ABCA1 in astrocytes (–54%, P < 0.001) and neuroblastoma cells (–70%, P < 0.001). Simvastatin reduced expression of apolipoprotein E in astrocytes (P < 0.01). Furthermore, both statins reduced expression of microtubule-associated protein tau in astrocytes (P < 0.01), while both statins increased its expression in neuroblastoma cells (P < 0.01). In SK-N-SH cells, simvastatin significantly increased cyclin-dependent kinase 5 and glycogen synthase kinase 3β expression, while pravastatin increased amyloid precursor protein expression. Our data suggest that simvastatin and pravastatin differentially affect expression of genes involved in neurodegeneration and that statin-dependent gene expression regulation is cell type specific.—Dong, W., S. Vuletic, and J. J. Albers. Differential effects of simvastatin and pravastatin on expression of Alzheimer’s disease-related genes in human astrocytes and neuronal cells.
Supplementary key words gene expression • ATP binding cassette transporter A1 • apolipoprotein E • phospholipid transfer protein • microtubule-associated protein tau • amyloid precursor protein
Abbreviations: AD, Alzheimer's disease; apoE/APOE, apolipoprotein E; APP, amyloid precursor protein; BBB, blood-brain barrier; CDK5, cyclin-dependent kinase 5; CSF, cerebrospinal fluid; DAB1, Disabled 1; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; GSK3β, glycogen synthase kinase 3β; MAPT, microtubule-associated protein tau; PLTP, phospholipid transfer protein
Thanks Waffle! I really need to know why I have been
subscribed for simvastin. Must be that you understand your
post, yet the unwashed have no idea what its about!
So I'll repost your article and hope that you can tell me:
1. What it means, and,
2. What it means"
Thanks! - a Simvastin client!
FYI, this wasnt *MY* article.
OK. you want to be smartass, fine. here you go.
Inhibitors of HMG-CoA reductase (statins) are widely used medications for reduction of cholesterol levels. Statin use significantly reduces risk of cardiovascular disease but has also been associated with lower risk of other diseases and conditions, including dementia. However, some reports suggest that statins also have detrimental effects on the brain.
basic intro
We provide evidence that simvastatin and pravastatin have significantly different effects on expression of genes related to neurodegeneration in astrocytes and neuroblastoma (SK-N-SH) cells in culture.
they dumped the stuff in a dish with some brain cells and some tumor cells to see what would happen
Simvastatin significantly reduced expression of ABCA1 in astrocytes and neuroblastoma cells (by 79% and 97%, respectively; both P < 0.001). Pravastatin had a similar but attenuated effect on ABCA1 in astrocytes (–54%, P < 0.001) and neuroblastoma cells (–70%, P < 0.001).
ABCA1 is a protein that helps cells remove (efflux) excess fats (cholesterols) and create HDL (good cholesterol). it performs this function all over the body.
Reducing this protein is an ominous sign that could signal the potential for side effects.
Tangier's disease is a genetic condition resulting from defective ABCA1 protein
Simvastatin reduced expression of apolipoprotein E in astrocytes (P < 0.01).
Apolipoprotein E helps metabolize and regulate cholesterols. problems with this protein are associated with Alzheimer's and cardiovascular disease. Reduction of this protein is Bad.
Furthermore, both statins reduced expression of microtubule-associated protein tau in astrocytes (P < 0.01), while both statins increased its expression in neuroblastoma cells (P < 0.01).
this tau protein is found in nerve cells. it helps stability and structure of these cells, and (when malformed) is also involved in Alzheimer's statins reduce this protein in normal cells and increase it in tumor cells
In SK-N-SH cells, simvastatin significantly increased cyclin-dependent kinase 5 and glycogen synthase kinase 3β expression, while pravastatin increased amyloid precursor protein expression.
cyclin-dependent kinase 5 is involved in brain development and the life cycle of brain cells. problems with this protein are related to brain problems, including alzheimers
glycogen synthase kinase 3β is involved in energy metabolism, neuronal cell development, and body pattern formation
amyloid precursor protein is involved in formation and repair of cellular signalling. not a lot is known about its primary function degradation of this protein generates some of the proteins found in the brains of Alzheimer's patients.
Our data suggest that simvastatin and pravastatin differentially affect expression of genes involved in neurodegeneration and that statin-dependent gene expression regulation is cell type specific.—Dong, W., S. Vuletic, and J. J. Albers. Differential effects of simvastatin and pravastatin on expression of Alzheimer’s disease-related genes in human astrocytes and neuronal cells.
conclusion, bla bla
the thrust of this summary, is that these drugs might have side effects of a neurodegenerative variety.
hope this sheds some light on your Simvas
tatin. my point was basically, dont be an asshole. if you dont want to read the article, why waste your time posting in it?