They’d have to really adjust the rules. Americans won’t take to a game that can take 3 days to play only to wind up in a tie. It’d have to be over, start to finish, in 3.5 - 4 hours or less.
I spent five years in Britain. Got to be a fanatic follower of Leeds United, Liverpool, inter alia. During the summers I TRIED to watch cricket and understand the game. After almost five years I still couldn’t figure out which side was winning. Some matches can go on for days. They have one-day matches as well and one can usually tell who won. I never saw any hooliganism at a cricket match.
20/20, the form of cricket being discussed here, does precisely that - and that's why the IPL believes that, unlike the more traditional forms of the game, 20/20 may have a chance in the US. 40 6-ball overs maximum, and it's all over. (That and the very large sums of money the IPL has at its disposal.)