Beam me to Planet Gore !
Unless I am mistaken, 4 seats if won by GOP-er's will get seated right away because they are replacements.
2 thru 4 of them would kill his ability to Cloture, all 4 would shut down the old bitties from Maine, and maybe even stop some of the other RINO's.
They are...
Biden's old seat ( DE )
Obama's old seat (IL)
Byrd's Seat ( VA) since he died in office and...
Hillary's Old Seat, (NY) i.e. now Gillibrands