I don’t understand your question.
Well, what does physics have to say about the question of one big launch versus lots of little ones? A simple thought experiment: Compare, in your mind, 10 launches carrying N/10 lbs. of fuel as payload versus 1 launch of N lbs. of fuel as payload. Suppose you strap the 10 smaller rockets together ( in thought ) and regard them as one launch. How are we doing here?