From the second link I posted:
“If a 150 pound deer can be shot through the heart with a .30-06 180-gr. expanding bullet at 2700 ft/sec and keep moving, should we expect that a 200 pound human hit with a 180-gr. expanding forty-caliber bullet at 975 ft/sec to be instantly incapacitated?
I believe it’s an unrealistic expectation to assume that any defensive pistol cartridge will deck a human being as though struck by lightning. It will happen on some occasions, but not all and probably not the majority.”
I found that happening with 180gr core-loc ammo. I switched to Nosler ballistic tips and the most a deer moved was straight down. Saw one actually flipped over and dropped on his back.