I assume so. Scalia has, in the Reynolds (CA firearm - homemade machinegun that never left the state) and Raich cases.
Funny thing about he Wickard case, the logic for its legal conclusion (Farmer Filburn affects interstate commerce if he is allowed to grow and consume his own wheat) is totally undermined by its factual findings (Filburn could have avoided the penalty by feeding it to his livestock without threshing it first).