On a air combat wargame website, some of the designers were trying to come up with a way of simulating the F-22 in their game. They came up with a humorous table for the F-22's opponent to use:
80% chance: you are shot down and have no idea why.
10% chance: you see the F-22 immediately before you are shot dow.
10% chance: you see the F-22 and eject before you are shot down.
This guy was, from all accounts, Sierra Hotel as a fighter pilot, and he said that not only was it not even close to being close, but "Any pilot not flying an F-22 who tells you he waxed an F-22 is simply full of crap."
I've heard there was one simulated battle flown by Air Force pilots where some F-15s or F-16s won against the F-22, but it was a set up lopsided battle to show how bad things would have to be for the F-22 to lose. If I remember the story, the F-22 wasn't allowed to have any AWACS support and was outnumbered at least 6-1, and the other planes came in from above and behind and even then it was still a very close battle.
Heh, reminds me of a game I was playing once (Warbirds) and you would killed as soon as you sat in your cockpit. Turns out there was a guy who parked his B-25 Mitchell (the one with the 75mm cannon) on the runway right behind where new planes would regenerate. As soon as they appeared in front of him, he would just pull the trigger and obliterate them. It took me a while to figure it out.
I am sure an F22 could get shot down, no weapon system is infallible or invincible, and 50% of the F-22 pilots have to graduate in the lower half of their F-22 class...