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Back just after 9/11 there was an article which interviewed some ME hardcore Islamists. They were asked what if Mecca were nuked and the Rock destroyed, would they still hold the faith?
They answered that allah is the supreme and only god, but if the rock were destroyed, then allah was not the supreme god, and so would not be followed any longer.
Most said they would convert to Christianity, some to Judaism, others to atheists.
I agree with that, but additionally, I believe many would go berserk and kill themselves, their families, or anybody else handy.