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To: neverdem

It would be nice if this technology were applied to cancer research. We may at long last find a cure for it.


2 posted on 04/08/2012 1:16:08 PM PDT by jonrick46 (Countdown to 11-06-2012)
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To: jonrick46
Crystallization is key chemical process both for pharmaceutical and industrial purposes. Some examples of how this sort of basic research could advance technology.

I worked with a pharmaceutical crystallization that was a 36 hour batch process and the crystal product formed had two stereo isomers, a right hand and left hand but identical in all physical/chemical respects otherwise. However, only the right hand was active as a therapeutic with the left hand being inert. A better understanding of the crystallization chemistry could yield a greater purity of the active right hand isomer and thus reduce production cost followed by reduced retail cost to the patient. By the way, production cost of this pharmaceutical chemical was several thousand dollars per pound.

Let's pick an ammonia fertilizer as an industrial crystallization with production costs of I don't know, say a buck pound. Purity is not near as strong a driver because the economic value of 95% versus 99%+ does not have as much value to the customer, the farmer in the field. It does though have a significant impact to the manufacturer as one aspect of the reduced purity are inclusions of the saturated reaction fluid trapped within pockets within the crystal lattice (imperfections). Lost reaction fluid means greater raw material costs to mix up the reaction fluid. Finally the point! LOL! If this basic research can shed light on what process variables favor or disfavor inclusion of reaction fluid in the crystal lattice then process factors can be adjusted minimize loss of reaction fluid and thus reduce production cost. Ultimately, this would mean more dollars to shareholders and lower cost to the farmer.

3 posted on 04/08/2012 2:03:58 PM PDT by Hootowl99
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