"The only good defense ammo is one that starts with a '4'"
Maybe, but shot placement counts for a lot more than caliber.
IMHO, the best defensive handgun is one that you will carry and practice with and be able to consistently double-tap with into a 10" kill zone at seven to ten yards. If you can do that, then there's a pretty good chance that you will be able to do what you need to do at five yards or less when subjected to a potentially deadly attack.