Typical DOT weigh station inspections do not involve cargo unless there is some sign that the cargo isn’t stable.
I get pulled over into one of these and you can damn well bet I’m telling them to bring a DOT officer over to give me Level 2 or 3 paperwork, and if they open my cargo they are giving me a level 1 or special level 4. I’m also calling company legal and company security as soon as my cargo seal gets broken.
Bingo. Not only is it an inconvenience & liability to them (TSA/LEOs), but it is only the responsible thing to do considering that the cargo is only under your care and it's owners should know when ANYTHING happens to it that should compromise its manifest (or timely delivery).