I still kick myself sometimes for not realizing that the large amount of paper that the copier across from my desk was going through was a sign of espionage. Make sure that both your classified and unclassified printers and copiers are audited, everyone.
Print only that which you absolutely need hardcopy of.
Intercept the hardcopy immediately upon creation.
Store all hardcopy securely, and store only that which you absolutely need to store.
Securely dispose of all hardcopy the instant you don't need it anymore. (Managers, do this personally. NEVER delegate document security. We had a massive breach because a Director let his assistant clean out his files. She was an eco-nut and put them in an open recycle bin in an unsecured area, from which most of them promptly vanished.)