Not sure any Republican can bring down Jay Nixon. Maybe if Republican voters can be convinced to vote Republican up/down the ballot...
If anyone can beat Jay Nixon, it's Bill Randles.
Check out his website (I don't know how to hot-link, but it's www.BillRandles.com ), "white papers" he has written, YouTube videos of speeches/forums, etc where he has spoken. As he says in the editorial, he has thought about policy issues, has positions, and will be ready to lead/govern immediately after his election.
Again, if anyone can defeat Jay Nixon, it is Bill Randles - and 2012 is the year!