I’ve heard a discussion of this. An analysis was done of the various calibers that people have been shot with and the results thereof.
It turns out the .22 didn’t perform much lower than the 9mm.
http://www.thetruthaboutguns.com/2012/06/foghorn/ask-foghorn-22l-for-self-defense/
>http://www.thetruthaboutguns.com/2012/06/foghorn/ask-foghorn-22l-for-self-defense/
I’m sorry but that data analysis is so bad that it is not even worth reading.
The rationalizations he uses to justify the efficacy of the .22lr are spurrious.
First he lauds its ability to kill (the % of incidents ending in fatality), then he dismisses the the lack of ability to incapacitate (by assuming user error).
You don’t use a self defense gun to kill, you use it to incapacitate. A .22 is deadly because it can cause a lot of hemorrhaging, but won’t kill you fast. Hence it won’t incapacitate. This fits the data presented.