Did you see 60 Minutes a couple weeks ago. They had a segment regarding robots taking over for so many of the tasks that humans currently perform. Many of these were the low skill labor jobs that are now being done in factories in China and India. They showed how a robot purchased for about $26k could learn a task and do that task 24/7 for 3 years(no coffee or potty breaks or sick days). It worked out to about $3/hour. This would be as cheap a current Chinese labor. The savings would be it could be manufactured right here in the USA.
Another part of the segment showed a robotic semi truck driver ,like you suggested in your post. It would be GPS guided and could follow electronic tracking built into the roadway.
They also showed a warehouse in Mass where robots fullfilled the orders coming in over the internet/sales office. The robots would travel around a warehouse the size of two football fields, and bring the items to the person that would then check the order, apply the shipping label and off it went to the shipping dept. The human would never actually leave their spot, the robot brought the items to them. It followed a tracking system built into the floor of the warehouse.
Plus nobody seems to be thinking about all the programming jobs that would develop from this, or the jobs to maintain these machines.