The gossip says that the White House is considering the nomination of Big Sis to a Supreme Court seat, as soon as one of the current walking dead creates an opening.
Thus, if this challenge to Federal law emerges as a test case, chances of a Supreme vote in favor of MO would be slimmer.
Their case for nullification would be no less Constitutional if the Supremes ruled against them. The Supremes would just be acting on behalf of an illegal over-reach. What was that Greek expression? "Come and take them."
As long as we continue to do that which has brought us to the brink of hard tyranny, gee, what can we expect?
Article V baby, an Article V amendment convention of the states is our only chance.