Still a wacky analogy.
But lots of components can’t be boil/steam/filter/sifted out of things.
a mixture can be separated by mechanical/physical means. So the sugar in 'grape drank' can separated by boiling off the aqueous portion and crystalizing the sugar. The sugar molecule however will remain unchanged.
or in biology, I can spin your blood down and separate the solids and the bits but the oxygen bonded to your prosthetic group of the porphyrin rings will remain chemically bonded.