[Eric Pode of Croydon]

Occam’s Razor. The plane suffered a major failure and crashed into the ocean.

[NY.SS-Bar9]

Doesn’t explain the transponder being turned off and active telemetry.

Could still be on the bottom of the ocean, but that would be either intentional (pilot suicide) or pilot error (fuel miscalculation).

[cuban leaf]

Occam’s Razor. The plane suffered a major failure and crashed into the ocean.

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Actually, I don’t think that is the Occam’s Razor answer. But that’s just me.