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Why Isn't There a Treatment or Vaccine for Ebola?
CBS8 ^ | Aug 01, 2014 | Maria Cheng

Posted on 08/02/2014 2:04:14 AM PDT by nickcarraway

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To: Mom MD

I’ve been wondering, do the anti-viral drugs that were developed for treating HIV have any effect on other viruses? What would happen if, as soon as a person was diagnosed with ebola, they were started on an anti-viral cocktail along with immune boosters and blood platelets?

I’m not a doctor, but I haven’t find any reason yet why this wouldn’t help.


61 posted on 08/02/2014 8:09:48 PM PDT by Ellendra ("Laws were most numerous when the Commonwealth was most corrupt." -Tacitus)
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To: exDemMom

http://www.dailymail.co.uk/health/article-2711733/When-life-saving-Ebola-vaccine-available-Four-different-drugs-development-preventative-jab-years-researchers-face-funding-woes.html

That drug may be the Tekmira compound mentioned here.


62 posted on 08/02/2014 8:56:45 PM PDT by Black Agnes
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To: Vermont Lt
“Ebola has never been an issue in the US”

Now if the U.S. nurse would be smart she would claim she got Ebola when she was having an abortion, or it first presented when she took her ACA mandated birth control pills.

Then we would see all the Hollywood actors lining up to do commercials to cure this terrible disease. No money though, (they don't do the horrible “donate” thing).

O, Reggy, and a pet MOOSE while in a swamp in Kenya would even Tweet for a solution (#no-bleed-like-sweat-now)!

Then the mooose would bleed out and die a sad death on screen.

O and Reg could ride off on that tandem bike with their matching hats/bonnets.

Very moving, very compelling.

63 posted on 08/02/2014 9:10:05 PM PDT by JSteff (It was ALL about SCOTUS.. We are DOOMED for several generations. . Who cares? Dem's did and voted!)
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To: Ellendra

They would only affect other viruses that have the same overall characteristics. I think that HIV and Ebola are different enough that the same antivirals would not work on both viruses.


64 posted on 08/02/2014 9:16:14 PM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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To: nickcarraway

Probably the person who would have found the cure for ebola was aborted by his/her mother.


65 posted on 08/02/2014 9:23:00 PM PDT by Salvation ("With God all things are possible." Matthew 19:26)
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To: Black Agnes
That drug may be the Tekmira compound mentioned here.

Maybe because I'm really tired, but I don't see the Tekmira drug mentioned in the article you linked.

The last I read about the Tekmira drug was that the phase 1 clinical trials had been halted and have not, to my knowledge, been restarted.

66 posted on 08/02/2014 9:33:31 PM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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To: Ellendra

The HIV drugs may or may not help, they are fairly specific. The reason the platelets drop and the patients bleed is actually because they clot everywhere. The virus causes clotting in all the smallish vessels, using up all the clotting factors and platelets, so the patients have nothing left to clot with and bleed everywhere

The medical name is DIC, or disseminated intravascular coagulation. Giving platelets rarely helps as they are just used up as fast as the patients own platelets. The immune system works just fine in these folks, unlike in HIV

The only treatment I am aware of is supportive care - fluids, pain relief etc, and the mortality rate is very high. Lots of work to be done on a very nasty disease we have now voluntarily invited on our soil. Lets hope the CDC has learned from some recent horrific breaches, and things go well, but I’m not very optomistic.


67 posted on 08/02/2014 9:38:20 PM PDT by Mom MD
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To: exDemMom

“CAMPAIGNERS URGE U.S. AUTHORITIES TO GIVE EBOLA DRUG GREEN LIGHT

Health campaigners are calling for U.S. authorities to speed up their approval of a new drug hoped to be the first cure for the deadly Ebola virus.

A petition, created on change.org, states: ‘One of the most promising is TKM-Ebola manufactured by Tekmira Pharmaceuticals.

‘This drug has been shown to be highly effective in killing the virus in primates and Phase 1 clinical trials to assess its safety in humans were started earlier this year.’”

But it was in phase III trials for influenza if it’s the compound I’m thinking of.


68 posted on 08/02/2014 10:22:17 PM PDT by Black Agnes
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To: exDemMom

Rabies is scary and used to be 100% fatal regardless. Pasteur provided a good chance with his vaccine, which works well if you know you need it in time. And if you’re at high enough risk I presume you can get the vaccine prophylactically. And now the Milwaukee protocol provides a smidgen of hope if you don’t seek Pasteur in time: a half dozen survivors out of three dozen attempts. Not great odds, but no longer 100% fatal once symptoms appear. I know you can get rabies without realizing you’ve been exposed, but absent vampire bats—which we do lack here—I think most victims would have at least some clue to get the shots. And the shots aren’t nearly as bad they used to be.


69 posted on 08/02/2014 11:36:03 PM PDT by JohnBovenmyer (Obama been Liberal. Hope Change!)
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To: steve86

I see the best Gasto in Memphis, he treats my Drug induced GERD, and clearly states long term use of Nexium or other acid blockers, causes Barret’s Esophagus.

Nexium
Bone density side effects, and Barret’s Esophagus
http://www.valleyhealthcancercenter.com/Cancer-Services/Barretts-Esophagus - GERD treatment

I have to have a Upper GI biopsy every 2 yrs for it.


70 posted on 08/03/2014 5:41:21 AM PDT by GailA (IF you fail to keep your promises to the Military, you won't keep them to Citizens!)
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To: sakic

True, which is why I call it an incestuous relationship.


71 posted on 08/03/2014 5:42:13 AM PDT by GailA (IF you fail to keep your promises to the Military, you won't keep them to Citizens!)
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To: Black Agnes

The Tekmira drug and the drug in phase 3 trials for influenza are different drugs, made by different companies. They work in different ways.


72 posted on 08/03/2014 8:17:55 AM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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To: exDemMom

Ok.

I’ve got so many pubmed windows open on so many different articles right now. I need to clean them up and sort them.


73 posted on 08/03/2014 8:21:00 AM PDT by Black Agnes
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To: JohnBovenmyer
Rabies is scary and used to be 100% fatal regardless. Pasteur provided a good chance with his vaccine, which works well if you know you need it in time. And if you’re at high enough risk I presume you can get the vaccine prophylactically. And now the Milwaukee protocol provides a smidgen of hope if you don’t seek Pasteur in time: a half dozen survivors out of three dozen attempts. Not great odds, but no longer 100% fatal once symptoms appear. I know you can get rabies without realizing you’ve been exposed, but absent vampire bats—which we do lack here—I think most victims would have at least some clue to get the shots. And the shots aren’t nearly as bad they used to be.

I am well aware of the specifics of rabies infection. What scares me is that bats have tiny bites, and sometimes people do not know they have been bitten. There was a recent case where the incubation period was years (determined because the patient was living in Australia for several years before developing rabies). Rabies is endemic in my area--several rabid animals have been found this year.

All of the successful Milwaukee Protocol attempts that I am aware of were young girls. I do not know if that is significant. I will continue to consider rabies 100% fatal once symptoms appear until a better protocol has been worked out.

I know a woman who was bitten by a rabid bat. I think she had been previously vaccinated. In any case, she is still alive, several months later.

74 posted on 08/03/2014 8:42:47 AM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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To: Black Agnes

Indeed. I am reading dozens of articles. The only way to keep everything straight is to print and catalog it.


75 posted on 08/03/2014 8:54:13 AM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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To: Vermont Lt

we hope. let’s take a poll, what country will be first
with one?


76 posted on 08/03/2014 4:05:53 PM PDT by cycjec
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"..only Spartan women give birth to real men"




Thank God for the real men who founded this country,
and for the real men who continue to sustain it

Please join the 300 by donating $100

77 posted on 08/03/2014 4:07:54 PM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: nickcarraway
I am not an immunologist or pharmacologist, but I have practiced medicine for 30+ years. We find that it seems very difficult, even refractory ,that RNA viral particles are very difficult to develop vaccines for. The AIDS particle is an RNA virus ( as opposed to a DNA) virus. We have many vaccines to prevent DNA virus disease, but not so many for RNA. Yes we have treatments for viral diseases, most of which ameliorate, not cure. The body's immune system does the curing and the protecting. The immune system is so rich in efficacy. It even has an amnestic response....that being, if someone was exposed to a viral disease as a child and 40 years later is exposed again, the "amnesia" of the immune systems turns off and an antigen-antibody response occurs. Truly amazing. Though we do not have a cure for the AIDs victim we have developed amazing treatments, and thus people are living for decades post diagnosis.

Food for thought about the question posted.

78 posted on 08/03/2014 4:22:07 PM PDT by Texas Songwriter
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To: nickcarraway
The short answer to the question is "because nobody'd gotten lucky yet." That's what it takes. The stuff is fantastically virulent, and requires a BSL-4 containment facility even to handle. Alexander Fleming isn't going to stumble across it in a used petri dish. There are (I believe, I can't seem to find current data) some 15 of these in the entire country. There, and only there, is where it can even be worked on.

The key to finding a vaccine for a virus is to manipulate the immune system to be primed to react to its presence. That is typically done with either a "dead" virus or an attenuated one, that is, one that displays the glycoprotein markers without causing the disease. This particular virus has a fantastically low threshold dose, perhaps as few as 10 virii. A vaccine would have to be perfect not to kill the patient, perfect to a level that process science could produce consistently. It might be done, yes, but not within the parameters that are perfectly safe for, say, mumps or chicken pox.

The challenge isn't doing it to make a profit, it's doing it at all.

79 posted on 08/03/2014 4:28:09 PM PDT by Billthedrill
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