After our "perfect world" was taken from "us"...
We live in a world where things are based on the laws of nature, i.e., physics. JUST the way Mr. Fry wanted it. After Adam /Eve, we now live in a world governed by rules and laws of gravity, thermodynamics, etc. No, outwardly visible "interference" or provable "meddling" from God anymore.
We are all subject to the same effect (pretty much) if we were to fall from a building, for example. Cells divide in a child in in the womb, and thanks to the laws of nature, defects just happen in the world governed by science. It's not fair, or right, or predictable in many cases. But it happens. If an inbred brother and sister have a kid, the kid will have issues. the kid didn't deserve this, but how would we explain it if two inbreds give birth to Tom Selleck or Kate Upton?
The world he complains about is the world HE wanted. the world that HIS KIND hasn't "saved" yet, because they are, after all, NOT God, but only human.
And God gave us Free Will instead of making us Mind-controlled robots.