IMO we are already at #3 while #2 is trying to get started.
As for nullification, I would simply advise caution... efforts should focus on states refusing to allow their resources to be used to enforce or facilitate Federal laws, policies, regulations or programs that they find objectionable, redundant or unconstitutional.
To go beyond that and try to “take” power or property is dangerous and extra-constitutional, inviting the most serious response imaginable.
Nullification, like other forms of political protest, must be used, but well within the bounds of the extremes. As has been said countless times, if we fail to learn from history...