Not likely to happen. Think it through. Urban areas are leftist. So in Texas you think Houston, Dallas, Austin, etc would agree to secede? Or counties around the urban areas would somehow coalesce and secede without the resources in the big cities?
We also no longer have great statesmen in the South like we did in the Civil War area. Yeah we have a few like Sessions and Cruz but not many and even Alabama’s governor is a RINO. There are no politicians calling for secession.
I don’t think secession is likely either.
But now that the SCOTUS has ruled same sex marriage is the law of the land and all such marriages must be recognized in all 50 states, short of secession, what can the states do?
The US Constitution in general, the 10th Amendment in particular, have been routinely ignored by the Federal government since at least the days of the New Deal.