Manchin has an uphill battle in ‘18 in increasingly GOP-reliable W. Virginia. I wouldn’t be surprised if he openly caucuses with McConnell to support Trump’s agenda. Nor would I really raise an eyebrow if he pulls a Lincoln Chaffee and turns into an R.
Not to mention that it is his daughter that is the CEO of the pharmaceutical company that raised the price of the Epi-Pen to astronomical heights.