In any population there will be people who a vaccine\medicine will cure, do nothing for, maim or kill. The number of maimed and/or killed will never be zero! Yes it sucks to win that lottery. My father later in life became deathly allergic to aspirin. Aspirin something as about as safe as safe can be.
Bingo, you’ve nailed it.
Everything in medicine, like everything in life, requires a cost-benefit analysis.
If a disease has a particularly high fatality rate then perhaps you roll the dice and take the vaccine. But the government now mandates vaccines for diseases that have never killed anybody.
Also I think there is a bit of the old Star Trek thing at work here. The needs of the many outweigh the needs of the few, or the one. If trials show a disease will likely cripple or kill 1 in 10,000 some public health bureaucrat decides that we can live writing them off.