Posted on 06/02/2022 8:38:40 AM PDT by bitt
New year, same topics: nutrition, healthy eating and slowing the downhill roll of aging. Eat this, not that — never that — and try this one weird thing to look younger, right? Advice spans the spectrum from dubious to scientifically supported, but there is an approach that sidesteps it all: eat less. Either in a specific time frame or in general, limiting calories safely is called caloric restriction, food restriction or fasting. It’s not a new idea, but fasting as a health practice hasn’t taken off, and Eduardo Chini, M.D., Ph.D., a Mayo Clinic researcher, knows why.
“One of the things that make us happy is interaction with food, interaction with other people, so it can be a social burden,” he says. “If you restrict calories all the time, you will probably be unhappy.”
But emerging research suggests health benefits are linked to eating less, so researchers want to know: How can people eat a slice of cake but benefit as if they’d only had a bite? Dr. Chini, and other researchers at Mayo and elsewhere, are researching the biological effect of caloric restriction to understand if its benefits can be replicated through medication.
If researchers can sort out the complex network of actions kicked off by eating less, they can potentially offer new options for a wide range of diseases.
Dr. Chini is an anesthesiologist and part of the Robert and Arlene Kogod Center on Aging at Mayo Clinic. “It is probably hard for people to understand why an anesthesiologist would be doing research in aging,” he says. “But I have access to almost every specialty, every single disease. And at the end of the day, I am a physician who is interested in helping patients and in the mechanism of disease.”
His team’s focus is the chemical reactions in cells ― all of which are grouped under the term “metabolism.” Over decades, they’ve picked apart the intricacies of metabolic networks and signals, and focused on a specific cellular process linked to how cells fuel themselves and do their job.
Homing in on a key pathway
As he researched caloric restriction in the late 1990s, Dr. Chini hit on a metabolic pathway activated by fasting that is essential to life. It starts when a living thing ― from yeast to fish to humans ― consumes a food containing the amino acid tryptophan or the B vitamin “starter” or precursors nicotinic acid, nicotinamide, nicotinamide riboside. The body breaks down those substances into the molecule NAD+, or nicotinamide adenine dinucleotide.
NAD+ works with hundreds of enzymes to help the body accomplish chemical tasks, including making energy for the cell. It is part of protein creation and DNA repair. The metabolism of NAD+ is so complex it was still somewhat mysterious when Dr. Chini’s team started investigating. The one thing researchers did know is that NAD+ levels in the body decline with aging, and that it might be linked to the diseases and dysfunctions associated with aging.
“For many years, people didn’t know how NAD+ was metabolized,” he says. “Our lab discovered in 2002 that the enzyme CD38 was the No. 1 enzyme-destroying NAD+, and over the years, evidence has mounted that levels of NAD decline during aging and in many disease states.”
From NAD+ and CD38 to aging ...more
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I take Tru Niagen NAD+ and set running PRs every year. Been doing it for four years. I am now within 20 seconds of the world record for the mile for my age. It just stops you from aging, and sets repair systems to maximum speed.
I do intermittent fasting
EASY, Never hungry. Eat pretty much what I want.
Love it
Keto with intermittent fasting. Works great.
What dosage do you take?
Cheapest place to buy?
My MD scoffs at dietary supplements. All the advocates are doing commercials. Balance of Nature has colorful ads on Fox News. One for veggies and one for fruit. So tell me, how long before one notices effects of Tru Niacin? I’ll give it a small try(investment). Scam(s)?
300 MG, direct from the company in 6 month batches
It takes about a week. It seems to be more noticeable in people that are already engaged in a vigorous exercise routine because you suddenly don’t require all the time to recover that you used to. Some people report heart palpitations though. I have also heard of GI distress side effects but I don’t have any of those.
There are quack additives splashed all over the fool's paradise of cable chanels.
Sleep aids, pain aids, fat busterd diet pills, all nonsense.
There have also been serious postings on FR about sleeping aids, eating aids, joint aids yada yada. There are also occasional postings of the "medicinals", Tylenall, Advill p.m. and the poisions they can become when mixed with off-the counter and quack products.
Ask a GOOD trusted doctor about alzheimers and over the counter/airwaves crap.
Please share your protocol.
Thank you.
Followung
I did a NAD+ infusion. I thought it may have been a placebo affect but my wife noticed an improvement in movement and not as sleepy... weird.
It was a gift from one of my kids and I’m thinking about doing that again.
Also following. I just started a course of semiglutide for weight loss. Only want to drop about 15 pounds which is right in the wheelhouse for semiglutide therapy.
I started eating only between 10am and 6 pm.
I thought it would be a hardship to not eat breakfast early
but didn’t bother me
I either would eat a typical breakfast or lunch. Nothing drastic, regular food.
A snack mid afternoon and then dinner by 7
Never hungry
So I started shorting the time to eat. between 11am
and 6:30
Now I only eat between 12 pm and 5:30 pm Sometimes I don’t eat a snack.
My portions have gotten smaller not on purpose but because I feel full and I pay more attention to balance and healthy foody
BUT if I want a cheeseburger and fries or pizza I eat it
I did lose weight lowered BP and feel great
but my biggest surprise is how easy it is to adapt. No special foods etc, just adjusting time.
I run early every morning and thought I would feel hungry but don’t.
It is ridiculously easy and does so much good
Niagen owns the patent, and hasn’t licensed manufacture, so any vendor buys it from them. Markups vary, so cheapest brand varies. No generics.
Niacinamide and 5-HTP are precursors and much cheaper, but no research to demonstrate effectiveness.
Eat less? That's UNAMERICAN! Take the pill.
My first 2 bottles of Tru-Niagen were $30. Next time I tried to buy, the price was near $70, so I put that on hold.
Thank you, and bears repeating a million, billion, trillion times. I start yelling at the radio or the TV when those damn fool things come on.
I get them direct for a little under $30/month. A bit pricey but it works so well for me that I would probably pay a lot more. Each bottle lasts 90 days now though so maybe you are seeing the same price.
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