“When they tried to make vaccines for SARS1 with whole killed virus, they met with spectacular failure in the animal trial phase. So of course he said that.”
IIRC the whole virus vaccine attempts for SARS-1 and MERS both resulted in something called “vaccine-associated enhanced disease”, VAED.
When the vaccinated animals were exposed to the wild virus they all died quickly, maybe from cytokine storms. I suspect that this is why none of the current SARS-2 vaccines outside of China attempted to use a whole virus.
That’s precisely what I recall. All went well during the initial phase with no animals harmed or sickened, but upon challenge (exposure to the virus), they displayed an exaggerated response compared to unvaccinated animals —yes, a cytokine storm or something like that.
That’s how some of the conspiracy theories got started that the mRNA vaccines for Covid19 “killed all the animals” during testing. Of course the SARS1 vaccines were not mRNA vaccines, but whole killed virus.
At the beginning of the pandemic, it was easy to find articles about the SARS1 vaccine development attempts, but now my Google-fu fails me. :(