Ashley is the half-sister of Beau Biden, Hunter Biden, and Naomi Biden, her father's children from his first marriage to Neilia Hunter. She is of English, French, and Irish descent on her father's side and English, Scottish, and Italian descent on her mother's side.
Biden was raised in the Catholic faith and was baptized at St. Joseph's on the Brandywine in Greenville, Delaware. During her childhood, her father served as a United States Senator from Delaware and her mother worked as an educator.
Biden attended Wilmington Friends School, a private school run by Quakers---the Religious Society of Friends in Wilmington.
Ashley served as the executive director of the Delaware Center for Justice from 2014 to 2019 and earlier worked in the Delaware Department of Services for Children, Youth, and Their Families.
In 2010, she began dating Howard Krein, a plastic surgeon and otolaryngologist, after being introduced by her brother, Beau. They married in a Catholic-Jewish interfaith ceremony at St. Joseph's on the Brandywine in 2012. Krein works at Thomas Jefferson University Hospital and as an assistant professor of facial, plastic, and reconstructive surgery at Thomas Jefferson University.
