[Howlin]

11 days? I was under the impression that Prozac took almost that long to start working.

[technochick99]

Prozac can take anywhere from 2 to 6 weeks to have an impact. If it does, it usually takes up to 6 months for the effects to fully make themselves know. And, that's assuming that it even works. Never did a darn thing for me!

[Nov3]

For someone who is sensitive to it, the effects can occur within a few days. For people with a normal metabolism according to Lilly it can take up to 6 weeks. Of course they have a much higher incidence of suicide during this period than the placebo in studies. Of course that is not the drug causing the suicides, the placebo is just more effective at controlling depression initially. < /sarcasm>

[Al B.]

Varies from person to person, but Prozac IS the longest acting of the SSRIs. Half-life is about a week. From the stuff I've read, I recall that it does take longer than 11 days to "work" for most people, but I suspect 11 days is within the normal distribution on time to efficacy, albeit on the low side. I'll have to check on that, though.

Paxil, OTOH, is the shortest acting. Half-life is less than a day, which is the reason so many interdose withdrawal problems have been reported for it.