[KellyAdmirer]

So just the wrong tiles over the wheel well get hit by the foam and damaged, causing the tire inside to overheat just enough to explode, forcing open the landing gear doors just enough to disrupt the air flow past the wing and get torn off, exposing the entire inside of the wheel well to more extreme heat, bursting the other tires which causes other tiles to fly off, which heats up the aluminum skin to the point of no return. ?

[TomT in NJ]

I believe the tires aren't inflated until just before the shuttle lands - probably to prevent any potential tire explosion from destroying the shuttle. Having said that, if the wheel cover fell off or the seal was breached by superhot plasma, then the shuttle wouldn't last too long.