Taurus has a large frame revolver now in .22 Hornet for serious varmint pistoleros. All types of varmints, one imagines.
Travis, have you seen that new rifle Kel-tec is coming out in .223. It's the SU-16. Sport Utility 16. It has room for spare mags in the buttstock and the foregrip splits in two halves and folds down into a bipod. I love new toys but I must wait until the thing gets out and gets some reviews that aren't in a gun mag before I will buy one.
They are also coming out with a .38 cal pistol (P3AT) in the size of their P32. That seems more practical to me. I might be able to pocket carry that at work, where I'm not supposed to carry.