Oprah clearly senses that there is something missing in her life, something important which establishes meaning and purpose. And like all those whom God has not opened their eyes to truth she flitters from religion to mysticism to humanism to whatever the new pop psychology de jure may be, all in a fruitless search to find meaning. The answer is right in front of her face but although she has eyes she cannot see. It is a sad phenomena - to be pitied. “What profiteth a man to gain the whole world if in the process he loses his soul?”
I think your comment is closest to it. What’s she’s engaging in used to be called Gnosticism. And, as you said, it is sad in all senses. Hopefully, at some point before it’s too late, she sees the errors of her ways. Bad enough that she has done this, but hasn’t she devoted some of her shows to promoting this to others? Never thought I’d say it. Time to pray for Oprah.