All it will take is one dirty nuke to make Israel economically nonviable, by contaminating enough of the central area that it's unhealthy to live and raise children there.
It doesn't even have to explode in Israel. One plane flying off-shore in international waters on a supposed flight to Egypt, detonating a cobalt device when the wind is blowing east, would do the job.
Sure about that?
I stand by my position. Israel is still a SUPERPOWER in that part of the world.