My dad came from southwest Missouri, growing up on a farm that harvested more rocks than any other crop. Along comes the Depression, and with the CCC camps and WPA, you would have thought that they would have become die-hard Dems. Not so. The family had been forced to leave the county they lived in at the beginning of the Civil War because of attacks by southern sympathizers. However they had voted in the past, the family was against session and therefore became hard core Republicans. Absolutely detested FDR and all Dems that followed him.
Pittsburgh is pretty conservative culturally speaking. Very Pro-Life. Not terribly gay friendly (though they are pounding on that door really hard). Yet those same people will vote 80+% Democrat because, rightly or wrongly, they feel it is in everyone’s best economic interests.