Jerusalem here is the object of God's wrath. It cannot, therefore, be defined as the Church:
"That upon you may come all the righteous blood shed upon the earth, from the blood of righteous Abel unto the blood of Zacharias son of Barachias, whom ye slew between the temple and the altar. Verily I say unto you, All these things shall come upon this generation. O Jerusalem, Jerusalem, thou that killest the prophets, and stonest them which are sent unto thee, how often would I have gathered thy children together, even as a hen gathereth her chickens under her wings, and ye would not! Behold, your house is left unto you desolate." (Mat 23:35-38)
the true Jerusalem is above and it is free. it is where Jesus Christ rules and we who are in Him are seated with Him in heavenly places.
in a sense the Church at the end does come under the wrath of God apostasy losing its first love.
God is not concerned about a city in the middle east called Jerusalem, once the temple veil was torn, it was a sign that Jesus Christ Himself is the temple, we who are in Christ are part of that holy temple as Paul explains in Ephesians 2:11-22.