We think that we’re it, but when you pull back and really look you can see how really insignificant we are - but yet God knows us, in all the infinite universe He knows us, individually.
Astronomers pointed the Hubble Space Telescope at the darkest patch of sky they could find and left the shutter open for ten days. Their goal was to take a galaxy census sample. The sky area is what you'd see through a drinking straw--about one-twelfth the moon's apparent diameter. There are only three foreground stars in this photo, recognizable by camera-spikes. Every other visible object is a distant galaxy. As a direct result, astronomers doubled their estimate of galaxies in the observable universe, to 400,000,000,000.
You make a profound point, but there is a fact which adds yet another depth to it. Under the physical laws God chose in creating this (finite) universe, it requires a universe this inconceivably immense in order to yield just this one planet capable of indefinitely supporting advanced life, and here we are. God created all this cosmos just for us, so of course He knows us.